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4.7 Clinical evidence of Hydroxytyrosol Current clinical evidence for HTY remains limited and is largely based on short-term intervention studies assessing biochemical and oxidative stressrelated biomarkers rather than definitive clinical endpoints and most available trials involve healthy individuals or populations at increased cardiometabolic risk, with intervention durations ranging from 3 to 26 weeks and daily HTY intakes typically between ~ 5 and 15 mg, either as purified supplements or through high-phenolic extra virgin olive oil [102]

Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis

Joint & Muscle Repair Studied for its role in repair of tendons, ligaments, and muscles, of interest for athletes and active individuals

Some individuals use it as part of a recovery-focused wellness plan because of its potential role in tissue repair and healing support

The transcription factor Sfp1 regulates the oxidative stress response in Candida albicans