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Homocysteine can either be remethylated to methionine or metabolized to cysteine through a transsulfuration pathway requiring vitamin B 6
This is due to more steps being required in manufacturing purified proteins compared to that of small molecule drugs (Lagasse et al., 2017)
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The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]
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