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Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions
An orally active allosteric GLP-1 receptor agonist is neuroprotective in cellular and rodent models of stroke
Jeek P, Holendov B, Jabrek M, et al
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It can either do this directly by binding to the enzyme's active site or indirectly by working as an antioxidant and facilitating the removal of free radicals
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