Protein increases thermogenesis during digestion and increases satiety too, which results in less consumption of other foods (and therefore calories), says Burrows
Research, including meta-analyses and systematic reviews, found that GLP-1 receptor agonists such as semaglutide can significantly increase total testosterone levels
Maintain systemic anti-inflammation: Long-acting agents like semaglutide and tirzepatide sustain anti-inflammatory effects that may deprive malignant cells of supportive inflammatory signals
Additionally, the serine protease dipeptidyl peptidase 4 (DPP4) limits the bioavailability of GIP, GLP-1, and GLP-2 by cleaving the first two amino acids, rendering them inactive (Knudsen and Pridal, 1996
Comorbid conditions also factor into dosing decisions