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As AFib continues to affect more patients worldwide, clinicians need new strategies to reduce risk and improve long-term outcomes, presenting author Kenneth Bilchick, MD, professor of cardiovascular medicine at the University of Virginia, explained in a statement These findings suggest GLP-1-RAs may influence heart rhythm through mechanisms beyond weight loss
4.1 The ApelinAPJ axis Apelin was identified as the endogenous ligand for the APJ receptor, a G proteincoupled receptor structurally related to the angiotensin II type 1 receptor but functionally distinct from the reninangiotensin system ( Despite these favorable metabolic effects, enthusiasm for apelin-based therapeutics waned due to its potent cardiovascular actions, including vasodilation and positive inotropy
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Each analysis was repeated in three independent experiments
These include: 1) oxidative stress and mitochondrial damage, where viral factors induce ROS accumulation and mitochondrial dysfunction, leading to cellular damage, impaired autophagy/mitophagy, and primed inflammatory pathways
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