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Mol Cell Biol 37
cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients
Because these tests dont always show the full picture, its best to measure at least two parameters before diagnosing a B12 deficiency
See Additional file 7 for the GSEA enrichment plots for all seven datasets
Communicate regularly: Keep your healthcare provider updated on your routine and any side effects you notice
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