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Discovery of the irreversible covalent FGFR inhibitor 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3- d]pyrimidin-7(8 H)-one (PRN1371) for the treatment of solid tumors
Other research indicates considerable weight regain within six months of ceasing treatment, so monitor energy and hunger cues closely in that period
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When to reduce the dose Dose reduction is not failure
In 2005, exenatide was approved as a kind of GLP-1 receptor agonists (GLP-1RAs) for the clinical treatment of type 2 diabetes mellitus (T2DM) as the first international incretin drug [6]
