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Melatonin reduced IL1- and HA release in GO and control OFs, whereas its inhibitory effect on IFN- release was significant only in GO OFs ( -carotene, Retinol, and Vitamin E Among other bio-available substances with antioxidant effects, -carotene seems to be rather promising for a use in GO patients

Genera Fifty-nine bacterial genera were definitively identified in the cecal samples

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Intermittent dosing approaches have also been proposed, although these remain experimental and lack prospective validation (65, 66)