Central nervous system effects include actions on hypothalamic appetite centers, contributing to reduced caloric intake and subsequent weight loss
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Beyond these principal sites of GLP-1R action, lower-level receptor expression has been documented in several additional tissues, including the heart, kidney, lungs, and testis (Pyke et al., 2014
Triglyceride content of the liver was found to decrease in a dose-dependent manner with increasing methionine ingestion