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As E2 and E3 mice are known to have increased longevity relative to E4 mice (Shinohara et al., 2020), this overall increase in cerebrovascular acylcarnitines could represent compensatory changes to supplement energetics with age, or act as a FA detoxification mechanism, a response which appears blunted in E4s
Even more striking, 86% of participants on the 12 mg dose achieved normal liver fat levels (below 5%) at 24 weeks
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