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However, reduced ERK (Extracellular signal-regulated kinases) phosphorylation in GNE deficient cells after IGF-1 treatment suggests downregulation of the ERK pathway

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Carnosine acts as a dietary AGE interceptor: in the gut it binds reactive carbonyl compounds (the chemical precursors of AGEs) before they can cross into circulation, reducing total AGE absorption and lowering the inflammatory burden that ultra-processed foods otherwise impose on the body

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