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It then asks why well-powered trials have largely failed where smaller studies and real-world data succeeded, with attention to brain exposure, trial design, and patient selection, and outlines what the next generation of studies will need to test the hypothesis properly

No one knows what ten or twenty years on GLP-1s will look likein real bodies, in everyday lives

You take a genuinely exciting area of science and overstate and misrepresent it to sell bunk, Caulfield said

This is a first in-human observation, with comparable pre-clinical evidence existing only in rodents

The most reliable approach is to increase the dose slowly