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In the SURMOUNT-5 head-to-head trial ( N Engl J Med , May 2025), tirzepatide produced 20.2% average weight loss compared to 13.7% with semaglutide over 72 weeks a 47% greater relative reduction
PlexusDx compounded semaglutide contains the identical active pharmaceutical ingredient (semaglutide) as Ozempic and Wegovy, but is manufactured by licensed 503A compounding pharmacies
Unlike small-molecule drugs, peptides are susceptible to degradation through hydrolysis, oxidation, and aggregation processes that can render the compound inactive or, in some cases, produce harmful breakdown products
If the application is accepted and approved, the medication could become available as early as late 2027, although the timeline will ultimately depend on the FDA review process
The primary and secondary endpoints were absolute change from baseline in body weight at week 48 and week 72, respectively
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