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investigated the activity of OXPHOS complexes in the saliva of 51 PMS patients and found abnormal activity of complexes I and IV [339]
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This maneuver was not fruitful and compound 26 displays a Ki value in the micromolar range in sharp contrast to what could be expected considering the results obtained after reduction of Ang IV or Nle-Ang IV, cf
metabolism in the liver via four pathways (a) Glucuronic acid conjugation (50%) This is probably the most desirable metabolic pathway to follow, yielding nontoxic metabolites excreted in the bile
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