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Example 5 Arg34GLP-1 (9-37) carries out the modification of terminal amino group: dissolving 1g of Boc-His (Trt) -Aib-OH in 10mL of dichloromethane, adding 0.37g of DCC, cooling to 0 , stirring for 30min, adding 0.22g of HOSu, stirring and reacting at the temperature for 12 hours, filtering, collecting filtrate, and spin-drying the filtrate to obtain a crude Boc-His (Trt) -Aib-OSu product
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GLP-1 is produced primarily by specialized cells, called L-cells, in the lining of your small intestine
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