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Though ideal, EE may not always be feasible in many recipients
These two actions result in a decreased FFA flux in the liver, improving insulin and IGF-1 signalling
Curr Top Cell Reg
On the other hand, low portal insulin levels (e.g., during prolonged fasting) reduce hepatic GHR expression, thereby reducing IGF-1 levels and increasing GH concentrations by the lack of IGF-1 feedback on pituitary GH secretion (Fig
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