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Your body requires large amounts of water to remove all the junk its constantly accumulating, including the pesticides, plastics, heavy metals, and other xenobiotics, as well as the normal waste products produced by your cells

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[oai_citation:1PubMed]( 2) Nitric-oxidemediated, largely endothelium-dependent vasorelaxation Aortic ring experiments showed vasodilation that was blunted by L-NAME and hemoglobin and attenuated without endotheliumconsistent with NO-mediated effects

the consistent association is what makes the pathway an interesting target, including for compounds such as 5-Amino-1MQ

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