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As such, we integrated treatment, clinical, demographic, disease diagnosis and genetic variables as predictors in models of both efficacy and side effects

The mobile phase consisted of a linear gradient system of phase A (60% acetonitrile/40% water solution containing 10 mM ammonium acetate and 0.1% formic acid) and phase B (isopropanol:acetonitrile, 9:1, v/v): 0 min 60% A, 2 min 57% A, 12 min 40% A, 12.1 min 25% A, 18 min 1% A, 19 min 1% A, and 20 min 40% A

Bai H, Yang B, Yu W, Xiao Y, Yu D, Zhang Q

Now, if you are taking high amounts of vitamin C, that could be a good thing because high amounts of vitamin C are pro-oxidative