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20 The folate and methionine cycles are interlinked by the rate-limiting enzyme methionine synthase (MTR), and are essential to produce SAM, the universal methyl donor (Figure 3A)
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Intracellular ROS production Intracellular reactive oxygen species (ROS) levels were measured in treated cells using the oxidant-sensitive probe 2,7dichlorofluorescein diacetate [H 2 DCFDA] 11
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