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Presented for research literature review only Leasure JE et al

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Liu, T., Liu, Y., Zhao, X., Zhang, L., Wang, W., Bai, D., Zhang, J

We also observed that mean enrichment of a substrate decreases monotonically with increasing Hamming distance to procaspase-1, consistent with our hypothesis that cleavage activity on single-residue substitutions is predictive of cleavage activity on higher-order combinations of substitutions (Supplementary Fig