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Some data also suggests that, if started early in the course of ALS, an ultra-high-dose of methylcobalamin may prolong ventilation-free survival
However, it is important to emphasise that whilst these mechanisms are biologically plausible, there is insufficient high-quality clinical evidence for glutathione supplementation as a treatment for fatty liver disease
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All procedures, including animal care, wound modeling, dosing, and termination, were performed according to the Experimental Animal Guidelines for Ethical Review of Animal Welfare (GB/T 35892-2018) and approved by the Tianjin University Institute Animal Ethics Committee with the assigned approval number TJUE-2023-236
After centrifugation, the pellets were resuspended in PBS, and the cell suspension was disrupted using an ultra-sonicator (Q125, Q-sonica, USA) in an ice bath for 15 min
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