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This usually improves as the body adjusts
Gallwitz B, Witt M, Paetzold G, et al
![how does glp-1 stimulates insulin secretion GLP-1R and Diabetes glp-1_analogs [TUSOM | Pharmwiki]](https://s3.amazonaws.com/production.scholastica/public/attachments/bd59d6e4-c76b-4a0f-853f-f18e54c05fbd/large/figure_2._principal_mechanisms_lead_by_glp-1r_activation.png)
Studies show that compared to GLP-1 medications: Blood sugar control improves more Appetite suppression is stronger Weight loss is greater Average weight loss with tirzepatide has been around 26 pounds, compared to about 10 pounds with GLP-1 medications alone
![how does glp-1 stimulates insulin secretion GLP-1R and Diabetes glp-1_analogs [TUSOM | Pharmwiki]](https://www.researchgate.net/publication/391280808/figure/fig3/AS:11431281960082052@1771815114173/Schematic-pathway-showing-release-of-insulin-by-GLP-1-Binding-of-GLP-1-with-GLP-1R.png)
Taking your GLP-1 medication in the morning can be great if you want to start your day with appetite control already activated
![how does glp-1 stimulates insulin secretion GLP-1R and Diabetes glp-1_analogs [TUSOM | Pharmwiki]](https://www.researchgate.net/publication/5915832/figure/fig1/AS:394639765983235@1471100860555/Summary-of-the-cellular-actions-of-GLP-1-that-lead-to-stimulation-of-insulin-secretion.png)
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