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"Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study"
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The immediate post-discontinuation period (days 1-14) typically shows minimal visible changes as existing improvements from recent GHK-Cu application persist through maintained dermal copper levels, ongoing collagen synthesis from recently stimulated fibroblasts, and continued anti-inflammatory effects from treatment-induced changes