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Murphy JA, et al
All BO procedures were given 1.5 units (or points), which equates roughly to 30 minutes per procedure, with 2 units (40 minutes) given to patients where BO segments were known to exceed 10cm in length
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In a 2003 in vitro experiment by Khavinson and colleagues, addition of micromolar concentrations of the peptide to cultured human somatic fibroblasts produced a measurable increase in telomerase reverse transcriptase activity and a corresponding extension of telomere length across 1020 passages, with cell cultures continuing to divide beyond the Hayflick limit observed in untreated controls
IGF-1 levels above 400 ng/mL may increase cancer risk and require immediate dose reduction or MK-677 discontinuation
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