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As shown here, other substrates like SDF-1 and BNP should also be taken into account and may help to better understand the therapeutic potential of DPP4 inhibitors
The idea is to skip the most expensive part of manufacturing, downstream purification, by keeping the expressed peptide locked inside the protective walls of edible cells
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41 However, these mice do not display alterations in baseline body weight, suggesting that GLP-1 receptor is not critical for body weight regulation under basal conditions
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