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Altrient was co-founded by Les Nachman after a life-threatening heart condition led him to explore alternative medicine
The Phase 3 study evaluated orforglipron, an investigational, once-daily oral small molecule glucagon-like peptide-1 (GLP-1) receptor agonist, for weight maintenance over 52 weeks after initial treatment for 72 weeks with the highest tolerated doses of Wegovy (semaglutide) or Zepbound (tirzepatide), in participants from SURMOUNT-5 who were offered the opportunity to be re-randomized to receive orforglipron or placebo
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2001 Dec;142(12):5182-9
Another study also indicated that exendin-4 improved memory impairment by dampening the AMPK/NF-B pathway, reducing levels of IL-1 and TNF-, and increasing synaptic protein levels (118)
