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Under OS, HIF-1 is stabilized via nitrogen oxide (NOX)/ROS, which upregulates glycolytic enzymes (SLC2A1 and HK) and inhibits mitochondrial respiration via PDK1 activation [222]
A prominent example of OIS is the H-Ras G12V mutation, which triggers senescence by inducing the DDR mediated by ROS 17
Second: a larger acute GH peak is a pharmacodynamic observation, not an outcome , and no published work establishes that stacking these two classes improves any clinical or functional endpoint
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Assessing the efficacy and mechanisms of Pycnogenol on cognitive aging from in vitro animal and human studies
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