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Lilly has new obesity drugs in its clinical development pipeline, including a monoclonal antibody treatment for obesity, as well as another potential new treatment thats a different class of drug than GLP-1s but behaves similarly

Prucalopride (Resolor or Resotran) is a highly selective serotonin receptor activator and appears to be safer than earlier serotonergic agents for constipation

The risk of hypoglycemia and associated fatigue increases significantly with combination therapy

2.4% placebo in STEP-1 (N=1,961) Compounding context / FDA has permitted compounding of certain GLP-1 drugs during shortage periods under 503A/503B pathways HRT candidate profile / symptomatic peri- or postmenopausal women, or men with confirmed hypogonadism (total testosterone below 300 ng/dL on two morning draws) Cost structure / cash-pay

Older adults are at higher risk of muscle wasting (sarcopenia)