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Poor absorption or gut disease Low stomach acid, celiac disease, inflammatory bowel disease, chronic diarrhea, pancreatic insufficiency or dysbiosis may reduce absorption of protein, B12 and other cofactors needed by one-carbon metabolism

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Towards tailored obesity treatment choices based on obesity-related complications Ectopic fat deposition in different organs results over time in progressive metabolic dysfunction and the development of organ-specific metabolic complications including T2D, MASLD/MASH and HFpEF [108]

VCP or -actin served as loading control