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"These findings should encourage regulatory agencies and clinicians to investigate further, given the heterogeneity of the human population." For anyone who is worried about undisclosed side effects aside from the physical ones, the European Medicines Agency has instigated a review of GLP1 agonists
Emerging phase 3b work has examined orforglipron in a maintenance role including a trial evaluating whether people who first lost weight on injectable incretin therapy can preserve that loss after switching to the oral agent
Evernorth's study found that more than 50% of those who take GLP-1s stop doing so within 12 months, limiting the data available on the medications for longer periods
So, if someone is having fewer meals or smaller meals, then they may also be hydrating less as a result
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