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A.ApicellaM

Isolated in the early 1970s, it has been extensively studied for its role in gene expression modulation, influencing over 4,000 genes linked to tissue remodeling and inflammation control

Wang, L., et al

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For example, branched-chain amino acids (BCAAs) promote inflammation-related metabolic programs through transporters and mechanistic target of mTORC1 (mTORC1) signaling, whereas under conditions of amino acid deprivation or energetic stress, starvation sensing mediated by GCN2 can restrict inflammasome activation and IL-1 production, causing supply and restriction to generate opposite immune outputs at different thresholds (54)