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Nausea, diarrhea, vomiting, and constipation were all more common in the retatrutide trial, with the largest difference seen in constipation

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Semaglutide primarily works by helping regulate appetite, slowing digestion, and improving blood sugar regulation

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Additionally, the treatment was associated with decreased expression magnitudes of pro-inflammatory cytokines, including IL-17, IL-23, and TNF-, in the affected skin tissue [201]

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