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Clinical Evidence on GLP-1 Therapy and Blood Pressure Outcomes The SUSTAIN trials, large randomized controlled studies of semaglutide in type 2 diabetes, documented systolic blood pressure reductions of 35 mmHg compared to placebo, with some participants experiencing drops exceeding 10 mmHg
[170] [171] In June 2025, the European Medicines Agency recommended that the product information for semaglutide medicines be updated to include non-arteritic anterior ischemic optic neuropathy (NAION) as a very rare side effect, [172] while the World Health Organization concluded that the risk management plan for semaglutide should be revised to include NAION as a potential risk
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When bloating, gas, or discomfort persist, tracking can add another layer of clarity by helping you see how digestion may be changing over time
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