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Endothelial dysfunction, which refers to an imbalance between various factors involved in relaxation and contraction, coagulation and anticoagulation, as well as inflammation and anti-inflammation, may play a substantial role in the pathogenesis of atherosclerosis and cardiovascular disease (94)
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This aligns with previous studies showing that IGF- 1 decline with age leads to endothelial dysfunction in multiple vascular beds, including the brain [18, 29], further supporting the notion that vascular IGF- 1 signaling is critical for overall tissue health