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(2) Metformin increases the concentration of GLP-1 in the gastrointestinal tract by inhibiting the activation of dipeptidyl peptidase-4 (DPP4), which in turn reduces the degradation of GLP-1 by DPP4 in the gastrointestinal tract (McCreight et al., 2016)

This pricing behavior is consistent with a settlement that, in substance, created a managed duopoly during the 180-day window where both Novartis and Sun captured elevated returns relative to a fully competitive generic market rather than a genuinely competitive LOE event

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