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Laboratory research demonstrates that FOXO4-DRI's selectivity stems from exploiting fundamental differences between senescent and healthy cell biology, particularly the paradoxical state where senescent cells are primed for apoptosis but protected by specific survival mechanisms

Hampton M

Deeply elucidating molecular anti-aging mechanisms, investigating interactions with other aging-related signaling pathways (such as mTOR, AMPK, etc.), improving the functional network, and providing theoretical support for more efficient anti-aging interventions

Gemcitabine promotes autophagy and lysosomal function through Erk- and Tfeb-Dependent mechanisms

The FoxO code