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Taken together, the evidence reviewed herein supports the view that melatonin constitutes a unifying biological axis through which circadian rhythms, sleep, nutrition, and oxidative balance intersect during aging

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Magnesium improves insulin sensitivity, which supports stable blood sugar, by helping insulin bind to its receptor on cells and by moving glucose transport proteins to the cell surface

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In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later