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Within genomically primed backgroundsmost notably tumors harboring PIK3CA and PTEN lesions or ARID1A lossER appears to potentiate PI3K/AKTMAPK signaling, coupling apoptosis resistance to epithelialmesenchymal plasticity, and promoting microenvironmental remodeling with pro-metastatic features
Nutrients, 2021, 13 (10), 3432
The NAD+-Dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
Zhou M, Wu X, Luo J, Yang G, Lu Y, Lin S, et al
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