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The Phase 3 ophthalmic program (RGN-259) comprises three completed dry-eye trials (ARISE-1 n=317, ARISE-2 n=601, ARISE-3 n=700) and one completed European neurotrophic keratopathy trial (SEER-3), all of which missed their pre-specified primary endpoints
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10.2174/13816128113199990421 100 SeiwerthS.RucmanR.TurkovicB.SeverM.KlicekR.RadicB.et al (2018)
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