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This mechanical stress can cause the peptide to denature (unfold), which destroys its biological activity
If your pen froze accidentally, do not use it
Diabetes Care 25 , 16991703 (2002)
Valcheva P, Cardus A, Panizo S, Parisi E, Bozic M, Lopez Novoa JM, Dusso A, Fernndez E, Valdivielso JM (2014) Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals
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