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10.1038/cddis.2014.221 56 ZhangQ.LiuJ.DengM
majority of TBI and stroke studies Mice Used for transgenic Alzheimers models (APP, APP/PS1) and excitotoxicity studies Humans Multiple clinical trials in stroke, dementia, and TBI populations Cell culture Cortical neurons, hippocampal cultures, endothelial cells for mechanistic studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 1,000 preclinical studies and numerous clinical trials, Cerebrolysin faces substantial translational challenges that significantly limit its therapeutic utility
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Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice
Consequently, immune cells, notably neutrophils and macrophages, are recruited to sites of crystal deposition
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