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P/Q-type calcium channel modulators
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"In the registrational trials for this medicine, cholelithiasis (acute gallstone disease) was reported in 1.6% of patients and led to cholecystitis in 0.6% of people living with obesity treated with semaglutide 2.4 mg
27 Importantly, GLP-1 action is short-lived, with a half-life of just 12 minutes in the bloodstream under normal physiological conditions, after which it is broken down by the enzyme dipeptidyl peptidase IV (DPP-4), resulting in a loss of its biological activity