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If weight goes up and down, up and down, metabolically it sets people up for functional decline down the road. Of course, in considering why patients discontinue, a large part of it is money, Emanuel said

Association of the metabolic dysfunction-associated steatotic liver disease with cardiovascular and kidney disease in patients with type 2 diabetes mellitus: a cross-sectional study

Thus, GDH knock outs exhibit impaired astrocytic glutamate oxidation and increased glutamine synthesis pointing to a more prominent cycling of glutamate which may be compatible with the observation that synaptic glutamatergic function remained intact (40)