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Besides modulating the anabolism and catabolism of certain amino acids, mTORC1 also controls their uptake into the cytoplasm by inducing and sustaining the cell surface expression of amino acid transporters
Morishita M, Peppas NA
Another consideration is that both medications can affect the gastrointestinal tract, albeit in different ways
This means that to deliver equivalent therapeutic effects, oral versions require much higher doses, increasing costs and side effects while producing variable results depending on food intake, gastric pH, and individual metabolism
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