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Antibodies derived from patients or clinical source were identified, formulated and administered via inhalation to target the receptor-binding domain (RBD) of the virus, thereby blocking its interaction with angiotensin-converting enzyme 2 (ACE2) receptors, which are widely spread on human epithelium 37,38,39,40,41,42,43,44

In contrast, the submucosal plexus (Meissners plexus) is located within the submucosa 29 and primarily controls epithelial secretion and absorption 30,31

This group forms a strong covalent bond with serum albuminthe most abundant protein circulating in the blood

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