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A key characteristic of the BBB compared to peripheral vasculature is the arrangement of endothelial cells, which include tightly sealed cell-to-cell contacts called tight junctions (Moyaert et al., 2023)

A small number of people are allergic to B12, but this is rare

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People with Heart Conditions or High Blood Pressure The caffeine in Excedrin is there to help constrict blood vessels and relieve headache pain, but it can also make your heart beat faster and raise your blood pressure

Corruble E, Legrand JM, Duret C, Charles G, Guelfi JD