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Pathway analyses repeatedly highlight abnormalities in glycolysis, lipid handling, tricarboxylic acid cycling, and glutathione-mediated redox regulation ( 4.7 Integrative serum omics for noninvasive monitoring Although multi-omics strategies continue to generate compelling insights, substantial barriers hinder translation into routine care

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Future therapies will need to combine neuron-directed approaches with strategies that modulate glial function, restore homeostatic communication across cell types, and exploit emerging biomarkers for early detection and patient stratification