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Women who were pregnant, nursing, had other female sexual dysfunctions, or had recent psychiatric diagnoses or substance use issues were excluded from the studies

A retrospective study showed that HbA1c improved significantly during the first year of treatment and this effect was maintained over four years, although the benefits plateaued after the first year

The concomitant RAAS activation, which increases ANG II levels, causes efferent arteriolar vasoconstriction with consequent increase in renal perfusion and glomerular hyperfiltration

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Patients with prediabetes experience particularly striking benefits