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Cacciatore, I., Cornacchia, C., Pinnen, F., Mollica, A., & Di Stefano, A

Beyond the immediate goal of weight loss, shedding excess pounds can significantly reduce pain and inflammation, improving the quality of life for individuals with chronic pain conditions

The two strategies are therefore not substitutes, and they have very different evidence profiles

Vincent, P

Conversely, nicotine may exert paradoxical inhibitory effects by activating immune pathways and inducing apoptosis, such as through stimulation of immature dendritic cells via PI3K/Akt signaling and modulation of caspase-3 and Cyclin B1 expression through 7-nAChR signaling [36]