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Loss of GPX4 protein expression in NRF1-deficient cells sensitized cells to ferroptosis, whereas in cells lacking GPX4, overexpression of NRF1 failed to inhibit ferroptosis

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However, constrained CD4 + /CD8 + T cells motility were also observed for different reasons when extracellular lactate concentration increased, mediated by SMCT2 on CD4 T cells and MCT1 on CD8 T cells, and was retrospectively shown to correlate with T cell function in RA synovia [116]